Description

7-Deaza-2',3'-Dideoxy-7-Iodo-Adenosine is a chemically modified nucleoside analog, specifically engineered for advanced biochemical research and development. This compound is valued for its role as a key intermediate and building block in the synthesis of novel antiviral agents and for probing nucleic acid structure and function. It is primarily utilized by research scientists and pharmaceutical developers in the fields of antiviral drug discovery, nucleic acid chemistry, and medicinal chemistry.

Application

• Antiviral Research: Serves as a critical precursor in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) for studying HIV and other viral infections.
• Biochemical Probes: Used to investigate enzyme mechanisms, particularly those of polymerases and kinases, due to its modified deaza and halogenated structure.
• Medicinal Chemistry: Acts as a versatile scaffold for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Nucleic Acid Analog Synthesis: Employed in creating modified oligonucleotides for diagnostic assays and mechanistic studies.
• Academic & Institutional Research: Fundamental tool in university and government labs for studying nucleotide metabolism and drug resistance pathways.
• Pharmaceutical Development: Intermediate in the cGMP-compliant synthesis of active pharmaceutical ingredients (APIs) for clinical trial materials.

Basic Information

Product Name	7-Deaza-2',3'-Dideoxy-7-Iodo-Adenosine
CAS No.	114748-70-8
Molecular Formula	C11H13IN4O2
Molecular Weight	360.15 g/mol
Synonyms	7-Iodo-7-deaza-2',3'-dideoxyadenosine; 7-Deaza-2',3'-dd-7-I-Ado; 7-I-7-deaza-ddA; 2',3'-Dideoxy-7-iodo-7-deazaadenosine; 7-Iodo-7-deaza-ddA; 7-Deaza-7-iodo-2',3'-dideoxyadenosine; 1-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-7-iodo-1H-pyrrolo[2,3-d]pyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our 7-Deaza-2',3'-Dideoxy-7-Iodo-Adenosine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.