Description

5'-Iodo-2',3'-Dideoxycytidine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and life science research. Its primary value lies in its role as a versatile synthetic intermediate for the development of antiviral and anticancer agents, particularly nucleoside reverse transcriptase inhibitors. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors who require high-purity intermediates for advanced drug discovery programs.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel nucleoside-based antiviral drugs.
• Antiviral Research: Used in biochemical studies targeting viral polymerases and reverse transcriptase enzymes.
• Medicinal Chemistry: Serves as a key scaffold for structure-activity relationship (SAR) studies to optimize drug efficacy and selectivity.
• Bioconjugation & Probe Development: Utilized for labeling and modifying oligonucleotides or other biomolecules due to the reactive iodine moiety.
• Academic & Institutional Research: Employed in universities and research institutes for fundamental studies in virology and oncology.
• Process Development: Used by process chemists to scale up and optimize synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5'-Iodo-2',3'-Dideoxycytidine
CAS No.	114748-57-1
Molecular Formula	C9H12IN3O3
Molecular Weight	337.11 g/mol
Synonyms	5'-Iodo-ddC; 1-((2R,5S)-5-(Iodomethyl)tetrahydrofuran-2-yl)-4-amino-2(1H)-pyrimidinone; 2',3'-Dideoxy-5'-iodocytidine; 5-Iodo-2',3'-dideoxycytidine; 5'-Iodo-2',3'-dideoxycytidine; ddC-5'-I; 4-Amino-1-((2R,5S)-5-(iodomethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 5'-Iodo-2',3'-Dideoxycytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.