Description

5'-O-(4,4'-Dimethoxytrityl)-N6-Pivaloyl-2'-Deoxyadenosine is a key protected nucleoside derivative, essential for the controlled synthesis of oligonucleotides. This compound provides critical protection for the 5'-hydroxyl and exocyclic amine groups, ensuring high coupling efficiency and sequence fidelity during automated solid-phase synthesis. It is a fundamental building block for research and production in pharmaceutical development, molecular diagnostics, and genetic research, where precise nucleic acid assembly is paramount.

Application

• Oligonucleotide Synthesis: As a phosphoramidite precursor for the automated solid-phase synthesis of DNA strands and antisense oligonucleotides.
• Therapeutic API Manufacturing: A critical raw material in the production of active pharmaceutical ingredients (APIs) for antisense and siRNA-based therapies.
• Molecular Biology Research: Used in academic and industrial labs for constructing probes, primers, and gene fragments.
• Diagnostic Reagent Production: Incorporated into the manufacture of labeled probes for PCR, sequencing, and microarray applications.
• Antisense Drug Development: Serves as a building block for creating modified oligonucleotides with enhanced stability and target affinity.
• Scale-up GMP Production: Suitable for use in cGMP environments for the large-scale, reproducible manufacture of therapeutic nucleic acids.

Basic Information

Product Name	5'-O-(4,4'-Dimethoxytrityl)-N6-Pivaloyl-2'-Deoxyadenosine
CAS No.	114745-11-8
Molecular Formula	C38H41N5O7
Molecular Weight	679.77 g/mol
Synonyms	5'-O-DMT-N6-Piv-dA; DMT-dA(Piv); N6-Pivaloyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine; 2'-Deoxyadenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(2,2-dimethyl-1-oxopropoxy)methyl]-; Protected 2'-Deoxyadenosine Derivative; dA(Piv) DMT; DMT-dAPiv; DNA Synthesis Building Block
EINECS	Contact for details

Quality Control

Our 5'-O-(4,4'-Dimethoxytrityl)-N6-Pivaloyl-2'-Deoxyadenosine is produced under stringent quality management systems to ensure batch-to-batch consistency for critical research and GMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.