Description

O6-Phenyl-2'-Deoxyinosine is a chemically modified nucleoside analog designed for advanced biochemical and pharmaceutical research. This compound is critical for studying DNA repair mechanisms, specifically the role of O6-alkylguanine-DNA alkyltransferase (AGT) and for probing mutagenic and cytotoxic effects. It serves as a key intermediate and research tool for scientists in oncology, molecular biology, and medicinal chemistry. The product is supplied to meet the stringent purity requirements of discovery and development laboratories globally.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies of DNA repair proteins like AGT.
• Oncology Research: Investigated for its role in understanding and overcoming chemotherapeutic drug resistance, particularly to alkylating agents.
• Medicinal Chemistry: Serves as a sophisticated building block for the synthesis of novel nucleoside-based therapeutics and probes.
• Molecular Biology: Employed in studies of mutagenesis and DNA damage response pathways.
• Academic & Pharmaceutical R&D: A vital tool for basic research and drug discovery programs focused on genetic stability and cancer biology.

Basic Information

Product Name	O6-Phenyl-2'-Deoxyinosine
CAS No.	114485-36-8
Molecular Formula	C16H16N4O4
Molecular Weight	328.32 g/mol
Synonyms	O6-Phenyl-2'-deoxyguanosine; 2'-Deoxy-O6-phenylguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-phenyl-1H-purin-2-one; O6-Ph-dG; 6-Phenoxy-2'-deoxyguanosine; 2'-Deoxy-O6-phenylinosine; O6-Phenyl-deoxyguanosine
EINECS	Contact for details

Quality Control

Our O6-Phenyl-2'-Deoxyinosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for research-grade biochemicals to support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.