Description

N(4)-Hydroxy-5-Fluorodeoxycytidine Monophosphate is a modified nucleoside monophosphate analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and active pharmaceutical ingredient (API) intermediate in the synthesis of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the development of nucleoside-based drugs targeting viral replication and cellular proliferation. The precise chemical modification at the N(4) position and incorporation of fluorine enhance its metabolic stability and biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of next-generation antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Investigated for its potential activity against a range of DNA viruses, including herpesviruses and hepatitis B virus (HBV).
• Oncology Research: Used in the development of chemotherapeutic agents that act by incorporating into DNA/RNA to inhibit tumor cell growth.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and DNA polymerase function.
• Prodrug Development: Utilized in creating prodrug forms designed for improved cellular uptake and targeted delivery.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	N(4)-Hydroxy-5-Fluorodeoxycytidine Monophosphate
CAS No.	114333-22-1
Molecular Formula	C9H13FN3O8P
Molecular Weight	341.19 g/mol
Synonyms	5-Fluoro-N(4)-hydroxy-2'-deoxycytidine 5'-monophosphate; 5-Fluoro-N4-hydroxy-2'-deoxycytidine 5'-monophosphate; 5-Fluoro-N4-hydroxy-deoxycytidine monophosphate; 5-F-dCyd(N4-OH)-MP; 5-Fluoro-N-hydroxydeoxycytidine monophosphate; N4-Hydroxy-5-fluoro-2'-deoxycytidine 5'-monophosphate; 2'-Deoxy-5-fluorocytidine N4-hydroxy-5'-monophosphate
EINECS	Contact for details

Quality Control

Our N(4)-Hydroxy-5-Fluorodeoxycytidine Monophosphate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines, and our quality control protocols are designed to meet the stringent requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.