Description

5-Fluoro-4-Thio-2'-Deoxyuridylate is a chemically modified nucleoside monophosphate analog of significant research interest. This compound is valued for its role as a key intermediate and biochemical tool in the development of novel antiviral and anticancer agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on nucleotide-based therapeutics and molecular biology.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving thymidylate synthase and other nucleotide metabolism pathways.
• Antiviral Agent Development: Serves as a precursor for compounds being investigated for activity against a range of DNA viruses.
• Oncology Research: Explored for its potential to be incorporated into DNA, disrupting replication in rapidly dividing cancer cells.
• Molecular Probe: Acts as a labeled or modified nucleotide probe for studying nucleic acid interactions and mechanisms.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5-Fluoro-4-Thio-2'-Deoxyuridylate
CAS No.	114319-04-9
Molecular Formula	C10H12FN2O8PS
Molecular Weight	370.25 g/mol
Synonyms	5-Fluoro-4-thio-2'-deoxyuridine 5'-monophosphate; 4-Thio-5-fluoro-2'-deoxyuridylic acid; 5-Fluoro-2'-deoxy-4-thiouridine monophosphate; 5-F-4-thio-dUMP; F4SdUMP; 5-Fluoro-4-thio-dUMP; 2'-Deoxy-5-fluoro-4-thiouridine 5'-phosphate; 4-Thio-5-fluorodeoxyuridylate
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4-Thio-2'-Deoxyuridylate is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.