Description

2',2'-Difluoro-2'-Deoxyuridine is a fluorinated nucleoside analog with significant biochemical and pharmacological relevance. This compound is a key intermediate in the synthesis of more complex antiviral and anticancer agents, particularly gemcitabine. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in nucleoside chemistry, oncology drug development, and antiviral research.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of the anticancer drug gemcitabine (Gemzar®).
• Antiviral Research: Used in the development and study of nucleoside-based antiviral compounds.
• Biochemical Research: Serves as a tool compound for studying enzyme mechanisms, particularly those involving DNA polymerases and kinases.
• Oncology Drug Discovery: Employed in preclinical research for developing novel chemotherapeutic agents targeting DNA synthesis.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for drug substance verification.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for fluorinated nucleosides.

Basic Information

Product Name	2',2'-Difluoro-2'-Deoxyuridine
CAS No.	114248-23-6
Molecular Formula	C9H11F2N2O5
Molecular Weight	265.19 g/mol
Synonyms	2',2'-Difluoro-2'-deoxyuridine; 2'-Deoxy-2',2'-difluorouridine; 1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; DFdU; 2',2'-Difluorodeoxyuridine; Gemcitabine Intermediate; Difluorodeoxyuridine
EINECS	Contact for details

Quality Control

Our 2',2'-Difluoro-2'-Deoxyuridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality standards are designed to meet the stringent requirements of pharmaceutical R&D and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.