Description

5'-O-(9-Phenylxanthen-9-yl)-2'-deoxynebularine is a specialized nucleoside analog derivative, primarily utilized as a key synthetic intermediate in advanced organic and medicinal chemistry. Its value lies in its role as a versatile building block for the synthesis of modified oligonucleotides and nucleotide-based prodrugs, enabling critical research and development. This compound is essential for pharmaceutical researchers, biotechnology companies, and academic institutions focused on antiviral drug discovery, antisense technology, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of nucleoside-based antiviral and anticancer prodrug candidates.
• Oligonucleotide Synthesis: Used as a protected monomer for the solid-phase synthesis of modified DNA and RNA strands for research and therapeutic applications.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies to explore new bioactive molecules.
• Bioconjugation: Acts as a linker or modifier for attaching nucleotide moieties to other molecules, such as proteins or delivery vehicles.
• Antisense & Gene Therapy Development: Employed in creating oligonucleotides designed to modulate gene expression for therapeutic purposes.
• Chemical Biology Probes: Utilized in the development of labeled nucleotides for studying enzymatic mechanisms and cellular processes.

Basic Information

Product Name	5'-O-(9-Phenylxanthen-9-yl)-2'-deoxynebularine
CAS No.	114155-96-3
Molecular Formula	C28H24N4O4
Molecular Weight	480.52 g/mol
Synonyms	9-(9-Phenyl-9H-xanthen-9-yl)-9H-purin-6-amine; 2'-Deoxynebularine 5'-O-(9-phenylxanthen-9-yl) ether; 5'-O-DMT-2'-deoxynebularine; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxynebularine; DMT-2'-deoxynebularine; 2'-Deoxynebularine DMT ether; 6-Amino-9-[5-O-[(9-phenyl-9H-xanthen-9-yl)]-2-deoxy-β-D-erythro-pentofuranosyl]-9H-purine
EINECS	Contact for details

Quality Control

Our 5'-O-(9-Phenylxanthen-9-yl)-2'-deoxynebularine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.