Description

8-(2-Carboxymethylthio)-Cgmp is a specialized biochemical compound, a derivative of cyclic guanosine monophosphate (cGMP), featuring a carboxymethylthio modification. This structural modification is critical for research into cell signaling pathways, particularly those involving protein kinases and phosphodiesterases. It serves as a valuable intermediate and research tool for pharmaceutical development, specifically in the study of cardiovascular and neurological disorders. This high-purity compound is essential for academic, biotechnology, and pharmaceutical R&D laboratories requiring precise biochemical probes.

Application

• Pharmaceutical Research & Development: Key intermediate in the synthesis of novel therapeutics targeting cGMP-dependent pathways.
• Biochemical Assay Development: Used as a standard or probe in enzymatic assays to study phosphodiesterase (PDE) activity and inhibition.
• Cell Signaling Studies: Investigates the role of cGMP analogs in intracellular signal transduction mechanisms.
• Academic Research: Fundamental tool for studying cardiovascular physiology, smooth muscle relaxation, and neuronal function.
• Reference Standard: Serves as a high-purity analytical standard for quality control in related API manufacturing.

Basic Information

Product Name	8-(2-Carboxymethylthio)-Cgmp
CAS No.	114115-66-1
Molecular Formula	C12H14N5O8PS2
Molecular Weight	451.37 g/mol
Synonyms	8-(Carboxymethylthio)guanosine 3',5'-cyclic monophosphate; 8-(2-Carboxymethylthio)-cGMP; 8-S-Carboxymethyl-cGMP; cGMP, 8-(carboxymethylthio)-; 8-(Carboxymethylthio)-cyclic GMP; 8-CMT-cGMP; Guanosine 3',5'-cyclic monophosphate, 8-(carboxymethylthio)-
EINECS	Contact for details

Quality Control

Our 8-(2-Carboxymethylthio)-Cgmp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.