Description

1H-Indole-2-Carbonyl Fluoride (9Ci) is a specialized fluorinated indole derivative, a high-value building block in advanced organic synthesis. Its core value lies in the reactive carbonyl fluoride group, which serves as a versatile handle for constructing complex heterocyclic and pharmaceutical intermediates. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, enabling the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent biologically active molecules, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new generation herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Material Science: Serves as a monomer or cross-linking agent for creating specialized polymers and advanced organic frameworks with unique electronic properties.
• Fluorination Chemistry: Acts as a fluorinating agent or a source of the carbonyl fluoride moiety for introducing fluorine atoms into complex molecular architectures.
• Peptide Mimetics & Drug Discovery: Employed in the design and synthesis of indole-based peptidomimetics and small-molecule drug candidates.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1H-Indole-2-Carbonyl Fluoride (9Ci)
CAS No.	114085-25-5
Molecular Formula	C9H6FNO
Molecular Weight	163.15 g/mol
Synonyms	1H-Indole-2-carbonyl fluoride; Indole-2-carbonyl fluoride; 2-Fluorocarbonylindole; 2-(Fluoroformyl)-1H-indole; 1H-Indole-2-carboxylic acid fluoride; 114085-25-5; 2-Carboxyfluoride-1H-indole
EINECS	Contact for details

Quality Control

Our 1H-Indole-2-Carbonyl Fluoride is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for research and process chemistry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.