Description

Cyclopropanecarbonyl Chloride, 2-(4-Fluorophenyl)- (9Ci) CAS NO 113903-99-4 is a specialized fluorinated cyclopropane derivative, serving as a critical acyl chloride intermediate in advanced organic synthesis. Its value lies in enabling the efficient introduction of the sterically constrained and metabolically stable cyclopropanecarbonyl moiety into target molecules. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorophenyl-cyclopropyl group can enhance biological activity and environmental stability.
• Chemical Biology & Proteomics: Employed as a reactive handle for activity-based protein profiling (ABPP) or for labeling biomolecules due to its electrophilic carbonyl chloride group.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique thermal or mechanical properties.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) producing custom compounds for client projects.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2-(4-Fluorophenyl)- (9Ci)
CAS No.	113903-99-4
Molecular Formula	C10H8ClFO
Molecular Weight	198.62 g/mol
Synonyms	2-(4-Fluorophenyl)cyclopropanecarbonyl chloride; (2-(4-Fluorophenyl)cyclopropyl)carbonyl chloride; 4-Fluoro-α-(chlorocarbonyl)benzenepropane; 1-(4-Fluorophenyl)cyclopropane-1-carbonyl chloride; 2-(p-Fluorophenyl)cyclopropanecarboxylic acid chloride; Cyclopropanecarbonyl chloride, 2-(4-fluorophenyl)-; 113903-99-4 (CAS)
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 2-(4-Fluorophenyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.