Description

3'-Deoxyadenosine-2',5'-Diphosphoimidazolide is a chemically modified nucleoside derivative, specifically an activated nucleotide analog. This compound matters as a critical synthetic intermediate and biochemical tool for the study and manipulation of nucleic acid structure and function. It is primarily needed by researchers and manufacturers in the fields of nucleic acid chemistry, oligonucleotide synthesis, and pharmaceutical development, particularly for creating modified RNA/DNA sequences and exploring enzyme mechanisms.

Application

• Oligonucleotide Synthesis: Serves as a key activated monomer for the solid-phase or solution-phase synthesis of oligonucleotides containing 3'-deoxyadenosine modifications.
• Biochemical Research: Used as a substrate analog to study the mechanisms of RNA polymerases, ligases, and other nucleic acid-processing enzymes.
• Antiviral & Anticancer Agent Development: Investigated as a precursor for the synthesis of nucleoside analogs with potential therapeutic activity against viruses and cancer cells.
• Probe and Diagnostic Reagent Manufacturing: Employed in the creation of labeled or modified nucleic acid probes for diagnostic assays and genomic research.
• Enzyme Inhibition Studies: Acts as a potent inhibitor for specific enzymatic pathways due to its non-hydrolyzable diphosphoimidazolide moiety.
• Metabolic Pathway Analysis: Utilized in tracing and understanding nucleotide salvage and incorporation pathways within cells.

Basic Information

Product Name	3'-Deoxyadenosine-2',5'-Diphosphoimidazolide
CAS No.	113888-20-3
Molecular Formula	C13H17N7O10P2
Molecular Weight	517.27 g/mol
Synonyms	2',5'-Di-O-phosphono-3'-deoxyadenosine imidazolide; Cordycepin-2',5'-diphosphoimidazolide; 3'-Deoxyadenosine 2',5'-bisphosphate imidazolide; 3'-dA-2',5'-DP-Im; Imidazolide of 3'-deoxyadenosine-2',5'-diphosphate; Adenosine, 3'-deoxy-, 2',5'-bis(dihydrogen phosphate), P'→P2-imidazolide; Activated 3'-deoxyadenosine diphosphate
EINECS	Contact for details

Quality Control

Our 3'-Deoxyadenosine-2',5'-Diphosphoimidazolide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. Due to its hygroscopic and moisture-sensitive nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO, and common aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.