Description

2'-o-Methyl-2-Thiouridine is a chemically modified nucleoside analog, a critical building block in oligonucleotide synthesis. This compound matters for its role in enhancing the stability, specificity, and nuclease resistance of synthetic RNA strands, which is paramount for advanced therapeutic and diagnostic applications. It is primarily needed by biotechnology and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA therapeutics, and molecular biology research tools.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of modified RNA oligonucleotides.
• Therapeutic RNA Development: Used in the research and production of siRNA (small interfering RNA) and antisense oligonucleotides for targeted gene silencing therapies.
• Diagnostic Probes: Incorporated into nucleic acid probes to improve hybridization stability and specificity for diagnostic assays.
• Structural Biology Studies: Employed to investigate RNA structure, function, and protein-RNA interactions.
• Aptamer Development: Utilized in creating chemically modified aptamers with enhanced binding affinity and serum stability.
• Research Grade Biochemicals: Serves as a high-purity reference standard and reagent in academic and industrial research laboratories.

Basic Information

Product Name	2'-o-Methyl-2-Thiouridine
CAS No.	113886-72-9
Molecular Formula	C11H16N2O6S
Molecular Weight	304.32 g/mol
Synonyms	2'-O-Methyl-2-thiouridine; 2-Thio-2'-O-methyluridine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl)-2-sulfanylpyrimidin-4-one; 2'-OMe-2-thioU; 2-Thiouridine, 2'-O-methyl-; 2'-O-Methyl-2-thioUridine; 4(1H)-Pyrimidinone, 1-[3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydro-2-furanyl]-2-mercapto-
EINECS	Contact for details

Quality Control

Our 2'-o-Methyl-2-Thiouridine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and cGMP-grade applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) with detailed specifications are provided and traceability is maintained for full quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.