Description

Guanylyl 5'-Phosphoramidate Ammonium is a high-purity nucleotide derivative essential for advanced biochemical research and synthesis. This compound serves as a critical building block and intermediate in the development of oligonucleotides and nucleotide-based pharmaceuticals. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in molecular biology, enzymology, and therapeutic discovery.

Application

• Oligonucleotide Synthesis: A key phosphoramidate monomer for the solid-phase synthesis of modified DNA and RNA strands.
• Enzymology Studies: Used as a substrate or inhibitor in research on GTP-binding proteins, polymerases, and other nucleotide-dependent enzymes.
• Pharmaceutical Intermediates: Serves as a crucial precursor in the synthesis of nucleotide prodrugs and antiviral agents.
• Bioconjugation: Facilitates the site-specific labeling of biomolecules for diagnostic assays and imaging probes.
• Biochemical Reagent: Employed in high-throughput screening (HTS) assays to study signal transduction pathways.
• Reference Standard: Used as an analytical standard in quality control for nucleotide-based products.

Basic Information

Product Name	Guanylyl 5'-Phosphoramidate Ammonium
CAS No.	113728-12-4
Molecular Formula	C10H19N8O10P
Molecular Weight	442.28 g/mol
Synonyms	5'-Guanylyl Phosphoramidate Ammonium Salt; GMP-NH2 Ammonium Salt; Guanosine 5'-Phosphoramidate; Guanosine-5'-monophosphoramidate; GMP-α-NH2; 5'-O-Phosphonamidoguanosine; Guanylyl Phosphoramidate; Ammonium 5'-O-phosphonamidoguanosine
EINECS	Contact for details

Quality Control

Our Guanylyl 5'-Phosphoramidate Ammonium is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.