Description

5'Deoxy-4',5-Difluorouridine is a fluorinated pyrimidine nucleoside analog with the CAS registry number 113548-97-3. This compound is a key synthetic intermediate in the development of novel antiviral and anticancer pharmaceuticals, where its modified sugar moiety provides metabolic stability and targeted activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleoside chemistry, medicinal chemistry, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of advanced antiviral and antineoplastic drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop novel nucleoside-based therapeutics.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleoside metabolism.
• Antiviral Pro-drug Development: Investigated for its potential in creating targeted treatments for viral infections.
• Oncology Research: Explored for its incorporation into compounds designed to disrupt cancer cell DNA/RNA synthesis.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	5'Deoxy-4',5-Difluorouridine
CAS No.	113548-97-3
Molecular Formula	C9H10F2N2O5
Molecular Weight	264.18 g/mol
Synonyms	4',5-Difluoro-5'-deoxyuridine; 1-((2R,4S,5R)-4-Fluoro-5-(fluoromethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5'-Deoxy-4',5-difluorouridine; 2',4'-Dideoxy-4',5-difluorouridine; DFdU; 4',5-Difluoro-2'-deoxy-5'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 5'Deoxy-4',5-Difluorouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.