Description

N6-Methyladenosine N1-Oxide is a chemically modified nucleoside derivative of adenosine, featuring methylation at the N6 position and oxidation at the N1 position. This specific modification makes it a valuable reference standard and a critical building block in biochemical and pharmaceutical research. It is primarily utilized by researchers and manufacturers in the fields of epigenetics, RNA biology, and medicinal chemistry. The compound, identified by CAS number 113509-54-9, is essential for studying RNA modifications and developing novel therapeutic agents.

Application

• Epigenetics & RNA Modification Research: Serves as a crucial reference standard for the study of N6-methyladenosine (m6A) and its oxidative derivatives in RNA.
• Biochemical Reagent: Used as a high-purity substrate or intermediate in enzymatic studies and metabolic pathway analysis.
• Pharmaceutical R&D: Acts as a key building block or impurity standard in the synthesis and quality control of nucleoside-based therapeutics.
• Diagnostic Development: Employed in the development of assays and kits designed to detect and quantify specific RNA modifications.
• Academic Research: Utilized in universities and research institutes for fundamental studies in molecular biology and chemical biology.
• Standards Manufacturing: Supplied to certified reference material (CRM) producers for creating analytical standards.

Basic Information

Product Name	N6-Methyladenosine N1-Oxide
CAS No.	113509-54-9
Molecular Formula	C11H15N5O5
Molecular Weight	297.27 g/mol
Synonyms	1-Oxo-N6-methyladenosine; N6-Methyl-1-oxoadenosine; N(6)-Methyladenosine 1-oxide; N6-Methyladenosine 1-N-oxide; 6-Methylaminopurine riboside 1-oxide; m6A 1-oxide; 9-β-D-Ribofuranosyl-N6-methyl-1-oxoadenine
EINECS	Contact for details

Quality Control

Our N6-Methyladenosine N1-Oxide is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.