Description

P(1),P(4)-Bis(5'-Adenosyl)-1,4-Dithiotetraphosphate is a specialized dinucleotide analog featuring a unique dithiotetraphosphate bridge, which confers distinct biochemical properties compared to standard adenosine polyphosphates. This compound is critical for researchers investigating nucleotide-dependent signaling pathways, enzyme mechanisms, and redox biology. It is primarily utilized in advanced biochemical research, pharmaceutical development for metabolic and cardiovascular targets, and as a high-value reference standard in analytical laboratories.

Application

• Biochemical Research: As a substrate or inhibitor for studies on adenylate kinase, ATP sulfurylase, and other nucleotide-interacting enzymes.
• Pharmaceutical Development: Investigation of novel drug targets in purinergic signaling, platelet aggregation, and cellular energy metabolism.
• Diagnostic Reagent Manufacturing: Potential use in formulating high-sensitivity assay kits for clinical diagnostics and life science research.
• Reference Standard: Serves as an analytical standard for HPLC, LC-MS, and NMR in quality control laboratories for nucleotide-based products.
• Enzymology Studies: Probing the mechanism of phosphate transfer and sulfur substitution in enzymatic reactions.
• Metabolic Pathway Analysis: Tool for studying altered nucleotide metabolism in disease models.

Basic Information

Product Name	P(1),P(4)-Bis(5'-Adenosyl)-1,4-Dithiotetraphosphate
CAS No.	113270-27-2
Molecular Formula	C20H26N10O12P4S2
Molecular Weight	828.47 g/mol
Synonyms	Adenosine-5'-P1,P4-dithiotetraphosphate; Ap4A dithio analog; Diadenosine 5',5'''-P1,P4-dithiotetraphosphate; 1,4-Dithio-P1,P4-bis(5'-adenosyl) tetraphosphate; 1,4-Dithio-diadenosine-5',5'''-tetraphosphate; Adenosine-5'-[P1-(5'-adenosyl)-P4-dithiotetraphosphate]; Dithio-Ap4A; Bis(5'-adenosyl) 1,4-dithiotetraphosphonate
EINECS	Contact for details

Quality Control

Our P(1),P(4)-Bis(5'-Adenosyl)-1,4-Dithiotetraphosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for research-grade biochemicals, and specifications can be aligned with customer requirements for specific projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.