Description

(5E)-Calcipotriene is a synthetic vitamin D3 analog, a high-purity active pharmaceutical ingredient (API) with the CAS registry number 113082-99-8. It is a critical compound for the development and manufacture of advanced topical dermatological treatments. This API is primarily required by pharmaceutical companies and research institutions focused on addressing hyperproliferative skin disorders.

Application

• Primary Active Pharmaceutical Ingredient (API) in topical formulations for psoriasis treatment.
• Key component in creams, ointments, and scalp solutions targeting plaque psoriasis.
• Research chemical for studying vitamin D receptor (VDR) pathways and cell differentiation.
• Reference standard for analytical method development and quality control in pharmaceutical labs.
• Intermediate for the synthesis of related vitamin D analogs and prodrugs.
• Formulation studies for enhancing skin penetration and stability of dermatological products.

Basic Information

Product Name	(5E)-Calcipotriene
CAS No.	113082-99-8
Molecular Formula	C₂₇H₄₀O₃
Molecular Weight	412.60 g/mol
Synonyms	Calcipotriol; MC 903; (5E,7E,22E)-9,10-Secochola-5,7,10(19),22-tetraene-1α,3β,24-triol; 1α,24-Dihydroxyvitamin D3; Daivonex; Dovonex
EINECS	Contact for details

Quality Control

Our (5E)-Calcipotriene is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical development and GMP manufacturing. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing identity, purity, and impurity profiles as per validated analytical methods (HPLC, IR).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.