Description

Enalkiren is a potent and selective renin inhibitor, representing a significant class of compounds for cardiovascular research. Its primary value lies in its ability to specifically target the renin-angiotensin system (RAS), a key pathway regulating blood pressure and fluid balance. This makes it a critical reference standard and research tool for pharmaceutical developers, academic institutions, and contract research organizations (CROs) focused on hypertension, heart failure, and related metabolic disorders.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control (QC) in drug discovery and development pipelines.
• Biochemical Research: Serves as a key pharmacological tool to study the physiology and pathophysiology of the renin-angiotensin system (RAS) in vitro and in vivo.
• Mechanism of Action Studies: Employed to investigate the specific inhibition of renin and its downstream effects on angiotensin production.
• Preclinical Development: Acts as a lead compound or comparator in the development of novel antihypertensive and cardioprotective agents.
• Academic Research: Utilized in university and institutional labs for cardiovascular disease modeling and therapeutic target validation.

Basic Information

Product Name	Enalkiren
CAS No.	113082-98-7
Molecular Formula	C30H41N5O4
Molecular Weight	535.68 g/mol
Synonyms	Enalkiren; A-64662; (2S,4S,5S)-5-[(t-Butoxycarbonyl)amino]-4-hydroxy-6-phenyl-2-(1-methylethyl)hexanoyl-L-histidyl-L-phenylalaninamide; Abbott-64662; A 64662; U-83374; Renin Inhibitor A-64662; (2S,4S,5S)-5-[(tert-Butoxycarbonyl)amino]-4-hydroxy-6-phenyl-2-(propan-2-yl)hexanoyl-L-histidyl-L-phenylalaninamide
EINECS	Contact for details

Quality Control

Our Enalkiren is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC purity assay, identity confirmation (IR, MS), and determination of residual solvents and moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.