Description

3,4-Difluorophenyl Isothiocyanate is a versatile and high-purity organic building block essential for advanced chemical synthesis. This compound is a critical reagent for introducing the thiourea or isothiocyanate functional group into complex molecular architectures, enabling the development of novel materials and active compounds. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for creating new drug candidates, crop protection agents, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of biologically active molecules, particularly for developing kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the difluorophenyl moiety for enhanced activity and stability.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, resins, and advanced functional materials.
• Chemical Research: An important reagent in organic chemistry laboratories for constructing heterocyclic compounds and conducting structure-activity relationship (SAR) studies.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for metal complexes and catalysts used in asymmetric synthesis.
• Fluorescent Probe Synthesis: Used as a building block for creating sensitive molecular probes and dyes for biochemical and diagnostic applications.

Basic Information

Product Name	3,4-Difluorophenyl Isothiocyanate
CAS No.	113028-75-4
Molecular Formula	C7H3F2NS
Molecular Weight	171.17 g/mol
Synonyms	1,2-Difluoro-4-isothiocyanatobenzene; 3,4-Difluorophenyl Mustard Oil; 4-Isothiocyanato-1,2-difluorobenzene; (3,4-Difluorophenyl)isothiocyanate; NSC 405124; 3,4-DFPITC; 3,4-Difluorobenzene Isothiocyanate; 1,2-Difluoro-4-isothiocyanato-Benzene
EINECS	Contact for details

Quality Control

Our 3,4-Difluorophenyl Isothiocyanate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to verify identity and purity. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with relevant regulatory frameworks, including REACH, and can supply material suitable for research and development under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.