Description

P1,P5-Di(Adenosine-5') Pentaphosphate, Periodate Oxidized Sodium Salt is a chemically modified nucleotide analog, specifically engineered for research and diagnostic applications. This compound is valued for its role as a potent and specific inhibitor of adenylate kinase, a key enzyme in cellular energy metabolism. It is primarily utilized by researchers in biochemistry, molecular biology, and pharmaceutical development for enzyme studies, assay development, and investigating nucleotide-dependent signaling pathways.

Application

• Biochemical Research: Used as a specific inhibitor of adenylate kinase (AK) isoforms in enzymatic studies and kinetic assays.
• Diagnostic Reagent Manufacturing: Incorporated into kits for the measurement of ATP and ADP levels in clinical and research settings.
• Metabolic Pathway Analysis: Employed to study cellular energy homeostasis, nucleotide metabolism, and mitochondrial function.
• Pharmaceutical Development: Serves as a tool compound for target validation and screening in drug discovery programs related to metabolic disorders and cancer.
• Enzyme Characterization: Utilized to determine the activity and specificity of adenylate kinase in purified protein samples or cell lysates.
• Academic Research: A key reagent for universities and research institutes focusing on bioenergetics and nucleotide signaling.

Basic Information

Product Name	P1,P5-Di(Adenosine-5') Pentaphosphate, Periodate Oxidized Sodium Salt
CAS No.	112966-12-8
Molecular Formula	C20H22N10Na4O22P5
Molecular Weight	1010.15 g/mol (as sodium salt)
Synonyms	Periodate-Oxidized Adenosine Pentaphosphate; P1,P5-Di(adenosine-5')pentaphosphate, periodate-oxidized; oAp5A; Oxidized Adenosine Pentaphosphate; Adenosine Pentaphosphate, Periodate Oxidized; Diadenosine pentaphosphate, periodate oxidized; Ap5A, periodate-oxidized sodium salt; Inhibitor of adenylate kinase
EINECS	Contact for details

Quality Control

Our P1,P5-Di(Adenosine-5') Pentaphosphate, Periodate Oxidized Sodium Salt is produced under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (UV Spectrophotometry)	≥ 90% (on anhydrous basis)
Water Content (Karl Fischer)	≤ 5.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.