Description

Calcipotriene is a synthetic vitamin D3 analog, specifically a calcitriol derivative, with the CAS registry number 112965-21-6. It is a critical active pharmaceutical ingredient (API) valued for its potent regulatory effects on skin cell proliferation and differentiation. This compound is essential for manufacturers in the pharmaceutical and dermatological sectors developing topical treatments for chronic skin conditions.

Application

• Primary Pharmaceutical API: Core active ingredient in prescription topical ointments, creams, and solutions for psoriasis.
• Dermatological Formulations: Used in combination therapies for plaque psoriasis, scalp psoriasis, and other hyperproliferative skin disorders.
• Veterinary Medicine: Potential application in topical treatments for similar dermatological conditions in animals.
• Research & Development: Serves as a key reference standard and biochemical tool in pharmacological studies of vitamin D receptor pathways.
• Cosmeceutical Precursor: Investigated for use in advanced skincare products targeting abnormal skin cell turnover.

Basic Information

Product Name	Calcipotriene
CAS No.	112965-21-6
Molecular Formula	C27H40O3
Molecular Weight	412.61 g/mol
Synonyms	Calcipotriol; MC 903; Daivonex; Dovonex; (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol; 1α,24(S)-Dihydroxyvitamin D3 cyclopropyl derivative
EINECS	Contact for details

Quality Control

Our Calcipotriene is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and specific identification tests. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.