Description

3'-Deoxy-3'-Fluoro-5-Fluorouridine is a fluorinated nucleoside analog with significant research and pharmaceutical development potential. This compound is valued for its role as a key intermediate in the synthesis of novel antiviral and anticancer agents, particularly as a precursor to more complex therapeutic nucleosides. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of nucleoside-based therapeutics. The product is supplied with a focus on high purity and batch-to-batch consistency to meet stringent research and development requirements.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating the mechanism of action, metabolism, and resistance profiles of fluoropyrimidine derivatives.
• Antiviral Drug Development: Serves as a precursor for compounds targeting viral polymerases and reverse transcriptases.
• Oncology Research: Employed in the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Radiopharmaceuticals: Potential use as a precursor for 18F-labeled compounds used in Positron Emission Tomography (PET) imaging.
• Process Chemistry: Used in scale-up and optimization studies for the commercial production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3'-Deoxy-3'-Fluoro-5-Fluorouridine
CAS No.	112668-56-1
Molecular Formula	C9H10FN2O5
Molecular Weight	260.19 g/mol
Synonyms	3'-Deoxy-3'-fluorouridine, 5'-deoxy-5-fluorouridine; 3'-Fluoro-3'-deoxy-5-fluorouridine; 5-Fluoro-3'-deoxy-3'-fluorouridine; 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione; 3'-F-5-FUrd; FdUrd analog
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-3'-Fluoro-5-Fluorouridine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can support development projects requiring compliance with current Good Manufacturing Practice (cGMP) guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.