Description

1,O(6)-Ethanoguanosine CAS NO 112529-18-7 is a chemically modified nucleoside analog, specifically an ethano-bridged derivative of guanosine. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a stable mimic of DNA adducts and its utility in probing nucleic acid structure and function. It is primarily sought by researchers and developers in the fields of medicinal chemistry, molecular biology, and oncology research, where it is used to study mutagenesis, DNA repair mechanisms, and as a potential building block for novel therapeutic agents.

Application

• Biochemical Research: Used as a stable analog to study the formation and repair of specific DNA adducts, particularly those induced by alkylating agents.
• Medicinal Chemistry: Serves as a key intermediate or reference standard in the development of nucleoside-based therapeutics targeting cancer and viral diseases.
• Molecular Biology Tools: Employed in the synthesis of modified oligonucleotides for probing enzyme-substrate interactions and nucleic acid conformation.
• Oncology Research: Acts as a critical tool for investigating mutagenic pathways and the mechanisms of carcinogenesis related to DNA alkylation damage.
• Analytical Reference Standard: Used in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for the identification and quantification of DNA modifications in complex biological samples.
• Academic & Institutional Research: Fundamental research in universities and institutes focused on DNA damage, repair, and the structural biology of nucleic acids.

Basic Information

Product Name	1,O(6)-Ethanoguanosine
CAS No.	112529-18-7
Molecular Formula	C₁₂H₁₅N₅O₅
Molecular Weight	309.28 g/mol
Synonyms	1,N2-Ethanoguanosine; O6-Ethylguanosine; 1,N(2)-Ethanoguanosine; 1,N2-Ethanoguanosine; Guanine, 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-2-hydroxy-1-(hydroxymethyl)ethano-; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-2-hydroxy-1-(hydroxymethyl)ethanoguanine; 1,O6-Ethanoguanosine; 1,O6-Ethanoguanosine
EINECS	Contact for details

Quality Control

Our 1,O(6)-Ethanoguanosine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and comprehensive impurity profiling. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to ensure traceability and compliance with your research requirements. Our quality systems are designed to support GLP (Good Laboratory Practice) and cGMP (current Good Manufacturing Practice) standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the product should be handled in a low-humidity environment and the container kept sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.