Description

Dalfopristin is a semi-synthetic streptogramin B antibiotic, a key component in the synergistic combination with quinupristin. This compound is crucial for its potent activity against Gram-positive bacteria, including multi-resistant strains. It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of advanced antibiotic formulations, such as Synercid®.

Application

• Active Pharmaceutical Ingredient (API) in the antibiotic combination product Quinupristin/Dalfopristin (Synercid®).
• Research and development of novel antimicrobial agents targeting resistant pathogens.
• Biochemical research for studying bacterial protein synthesis and ribosomal function.
• Manufacturing of reference standards and analytical controls for quality assurance in pharmaceutical production.
• Investigation of synergistic antibiotic mechanisms and combination therapies.

Basic Information

Product Name	Dalfopristin
CAS No.	112362-50-2
Molecular Formula	C34H50N4O9S
Molecular Weight	690.85 g/mol
Synonyms	Dalfopristin; RP 54476; Streptogramin B, 4''-Deoxy-4''-[(2-diethylamino)ethyl]amino-; (3R,4S,5R,8R,9S,10S,11R,12S,13S,14S)-4-[[2-(Diethylamino)ethyl]amino]-3,5,9,11,13-pentahydroxy-8,10,12-trimethyl-1-oxa-6-azacyclopentadecan-2,15-dione; Component of Quinupristin/Dalfopristin; Component of Synercid
EINECS	Contact for details

Quality Control

Our Dalfopristin is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and MS, and residual solvent analysis, to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications and supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Total Impurities (HPLC)	≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.