Description

n-Acetyl-Guanosine 2',3',5'-Triacetate 6-(N,n-Diphenylcarbamate) is a chemically modified nucleoside derivative, specifically engineered for advanced research and synthesis applications. This compound is a critical high-purity intermediate for the development of novel oligonucleotides, prodrugs, and other bioactive molecules. It is essential for pharmaceutical R&D, biotechnology, and academic laboratories focused on nucleic acid chemistry and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of modified oligonucleotides and nucleotide prodrugs for therapeutic applications.
• Antiviral Drug Research: Used in the development and study of nucleoside analogs targeting viral polymerases.
• Bioconjugation & Probe Synthesis: Serves as a precursor for creating labeled nucleotides used in diagnostics and molecular biology probes.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Academic & Industrial R&D: Fundamental reagent for exploring new synthetic pathways in nucleic acid chemistry.
• Process Chemistry Development: Used in scaling up synthetic routes for nucleotide-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-Acetyl-Guanosine 2',3',5'-Triacetate 6-(N,n-Diphenylcarbamate)
CAS No.	112233-75-7
Molecular Formula	C33H32N6O11
Molecular Weight	688.65 g/mol
Synonyms	Guanosine, 2',3',5'-tri-O-acetyl-N2-acetyl-6-(N,N-diphenylcarbamate); 6-O-(Diphenylcarbamoyl)-2',3',5'-tri-O-acetyl-N2-acetylguanosine; N2-Acetyl-2',3',5'-tri-O-acetylguanosine 6-(N,N-diphenylcarbamate); N-Acetyl-6-O-(diphenylcarbamoyl)-2',3',5'-tri-O-acetylguanosine; Protected N-Acetyl Guanosine Derivative; Acetylated Guanosine Carbamate Ester
EINECS	Contact for details

Quality Control

Our n-Acetyl-Guanosine 2',3',5'-Triacetate 6-(N,n-Diphenylcarbamate) is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.