Description

N2-(Dimethylaminomethylidene)-7-Deaza-2'-Deoxyguanosine is a high-purity, modified nucleoside derivative of significant importance in advanced oligonucleotide synthesis and pharmaceutical research. This compound serves as a critical building block for the preparation of oligonucleotides with enhanced stability and specific binding properties. It is primarily utilized by research institutions and manufacturers in the fields of therapeutic nucleic acid development, diagnostic probe synthesis, and biochemical research.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for solid-phase synthesis of modified DNA and RNA strands.
• Antisense & siRNA Therapeutics: Used in the development of stable, nuclease-resistant antisense oligonucleotides and small interfering RNA (siRNA) for gene silencing applications.
• Diagnostic Probes: Manufacture of fluorescently labeled or otherwise tagged probes for in situ hybridization (FISH) and PCR-based diagnostics.
• Structural Biology Studies: Incorporation into oligonucleotides to study nucleic acid structure, stability, and protein-nucleic acid interactions.
• Aptamer Development: Synthesis of modified DNA libraries for SELEX (Systematic Evolution of Ligands by Exponential Enrichment) to generate high-affinity aptamers.
• Research Reagent: Serves as a specialized biochemical reagent in academic and industrial research laboratories.

Basic Information

Item	Detail
Product Name	N2-(Dimethylaminomethylidene)-7-Deaza-2'-Deoxyguanosine
CAS No.	111902-68-2
Molecular Formula	C13H17N5O4
Molecular Weight	307.31 g/mol
Synonyms	7-Deaza-2'-deoxyguanosine, N2-(dimethylaminomethylene) derivative; 2'-Deoxy-7-deazaguanosine, N2-(dimethylaminomethylene)-; N2-Dimethylaminomethylidene-7-deaza-2'-deoxyguanosine; 7-Deaza-dG(DMF) amidite precursor; N2-(Dimethylaminomethylene)-2'-deoxy-7-deazaguanosine; Modified nucleoside for oligonucleotide synthesis; c7dG(DMF) nucleoside
EINECS	Contact for details

Quality Control

Our production of N2-(Dimethylaminomethylidene)-7-Deaza-2'-Deoxyguanosine adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.