Description

7-Deaza-Ddg is a specialized nucleoside analog with the CAS number 111869-49-9, designed for advanced biochemical and pharmaceutical research. This compound is a critical building block in the synthesis of modified oligonucleotides, enabling the study of nucleic acid structure, function, and therapeutic potential. It is primarily utilized by research scientists and process developers in the fields of antiviral drug discovery, molecular diagnostics, and oligonucleotide therapeutics.

Application

• Antiviral Drug Development: Used as a key intermediate in the synthesis of nucleoside analogs targeting viral polymerases.
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite or solid-support reagent for introducing 7-deaza modifications into DNA/RNA strands to enhance stability and alter hybridization properties.
• Biochemical Research: Employed in mechanistic studies of enzyme-nucleic acid interactions, particularly with DNA/RNA polymerases and repair enzymes.
• Diagnostic Probe Design: Incorporated into nucleic acid probes to improve specificity and signal-to-noise ratios in assays like PCR and FISH.
• Therapeutic Oligonucleotide Manufacturing: A potential raw material in the GMP-compliant production of antisense oligonucleotides, siRNA, and aptamers.
• Academic Research: Fundamental tool for studying genetic code expansion and the development of novel xenonucleic acids (XNAs).

Basic Information

Product Name	7-Deaza-Ddg
CAS No.	111869-49-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7-Deaza-2'-deoxyguanosine; 7-Deaza-2'-deoxy-7-iodoguanosine; 7-Iodo-7-deaza-2'-deoxyguanosine; 7-Deaza-dG; c7I-dG; 2'-Deoxy-7-iodo-7-deazaguanosine; 7-Iodo-7-deazaguanosine 2'-deoxyriboside
EINECS	Contact for details

Quality Control

Our 7-Deaza-Ddg is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or GMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.