Description

1-Pyrrolidinecarboxylic Acid, 2-(Chlorocarbonyl)-, Ethyl Ester, (2S)- (9Ci) is a high-purity, chiral building block of significant importance in advanced organic synthesis. Its core value lies in its bifunctional nature, featuring both a protected amino acid moiety and a reactive acid chloride group, enabling precise stereocontrolled construction of complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of proline-based drug candidates, peptidomimetics, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and development of chiral herbicides, fungicides, and plant growth regulators.
• Peptide Chemistry: Serves as a protected and activated amino acid derivative for solid-phase and solution-phase peptide coupling reactions.
• Asymmetric Catalysis: Employed in the preparation of chiral ligands and organocatalysts for stereoselective transformations.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules to study protein function and interactions.
• Material Science Research: A precursor for designing novel polymers and functional materials with specific chiral properties.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 2-(Chlorocarbonyl)-, Ethyl Ester, (2S)- (9Ci)
CAS No.	111492-60-5
Molecular Formula	C8H12ClNO3
Molecular Weight	205.64 g/mol
Synonyms	(S)-1-(Ethoxycarbonyl)-2-pyrrolidinecarbonyl Chloride; L-Proline, 1-(ethoxycarbonyl)-, chloride (9CI); (2S)-1-(Ethoxycarbonyl)pyrrolidine-2-carbonyl Chloride; N-Carbethoxy-L-prolyl Chloride; N-Ethoxycarbonyl-L-proline Chloride; N-Cbz-L-Proline Acid Chloride (common misnomer); (S)-N-Ethoxycarbonylprolyl Chloride; Ethyl (2S)-2-(chlorocarbonyl)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxylic Acid, 2-(Chlorocarbonyl)-, Ethyl Ester, (2S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.