Description

Methyl 2-(2-((chlorocarbonyl)methyl)-1,3-dioxolan-2-yl)acetate is a specialized organic ester and acid chloride derivative, serving as a high-value synthetic intermediate. Its core value proposition lies in its bifunctional reactivity, offering both a protected carbonyl group and a highly reactive acid chloride moiety for selective transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who require precise molecular construction for complex target molecules, such as active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those requiring the controlled introduction of carboxylic acid derivatives or protected diol functionalities.
• Peptide Mimetics & Prodrug Synthesis: Used to construct peptide backbones or as a linker for creating prodrug formulations where controlled release is desired.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing specialized polyesters or functional polymeric materials with tailored properties.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, or plant growth regulators that incorporate ester and acid chloride chemistry.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing novel chelating ligands or organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes or labeling reagents for studying enzymatic activity and protein interactions.

Basic Information

Product Name	Methyl 2-(2-((Chlorocarbonyl)Methyl)-1,3-Dioxolan-2-Yl)Acetate
CAS No.	111463-18-4
Molecular Formula	C8H11ClO5
Molecular Weight	222.62 g/mol
Synonyms	2-(2-((Chlorocarbonyl)methyl)-1,3-dioxolan-2-yl)acetic acid methyl ester; Methyl (2-(2-(chloroformyl)methyl)-1,3-dioxolan-2-yl)acetate; Acetic acid, 2-[2-[(chlorocarbonyl)methyl]-1,3-dioxolan-2-yl]-, methyl ester; Methyl 2-(2-(chlorooxomethyl)methyl)-1,3-dioxolan-2-yl)acetate; 1,3-Dioxolane-2-acetic acid, 2-[(chlorocarbonyl)methyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-(2-((chlorocarbonyl)methyl)-1,3-dioxolan-2-yl)acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis of the acid chloride functionality. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.