Description

3-Hydroxyethyldeoxyuridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a crucial building block and intermediate for the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. Its primary value lies in enabling the development of next-generation nucleotide-based pharmaceuticals that target specific enzymatic pathways. Key industries that utilize this high-purity intermediate include pharmaceutical R&D, biotechnology, and fine chemical synthesis for active pharmaceutical ingredient (API) manufacturing.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and related pathways.
• Prodrug Development: Serves as a modified scaffold for creating prodrugs with enhanced bioavailability and targeted delivery.
• Antiviral Agent Synthesis: Integral to the research and development of compounds targeting viral polymerases and reverse transcriptases.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., deuterated, C13) compounds for metabolic and pharmacokinetic studies.
• Oligonucleotide Chemistry: Can be incorporated into oligonucleotide sequences to study structure-activity relationships and modulate biological activity.

Basic Information

Product Name	3-Hydroxyethyldeoxyuridine
CAS No.	111447-33-7
Molecular Formula	C11H16N2O6
Molecular Weight	272.25 g/mol
Synonyms	1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(2-hydroxyethyl)pyrimidine-2,4(1H,3H)-dione; 5-(2-Hydroxyethyl)-2'-deoxyuridine; 3-Hydroxyethyl-2'-deoxyuridine; HE-dU; 3-HEdU; 5-(2-Hydroxyethyl)deoxyuridine; 1-(2-Deoxy-β-D-ribofuranosyl)-5-(2-hydroxyethyl)uracil
EINECS	Contact for details

Quality Control

Our 3-Hydroxyethyldeoxyuridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' regulatory and compliance needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.