Description

Triethylammonium Uridine-3',5'-Cyclic Phosphorothioate is a chemically modified nucleotide analog where a sulfur atom replaces one of the non-bridging oxygen atoms in the cyclic phosphate moiety. This compound is a critical biochemical tool for studying cyclic nucleotide signaling pathways and enzyme mechanisms, particularly as a substrate or inhibitor for phosphodiesterases and protein kinases. It is essential for researchers and developers in pharmaceutical discovery, molecular biology, and enzymology who require high-purity, well-characterized nucleotide derivatives for advanced research applications.

Application

• Biochemical Research: Used as a substrate analog to investigate the catalytic mechanisms of phosphodiesterases (PDEs) and other nucleotide-metabolizing enzymes.
• Enzyme Inhibition Studies: Serves as a competitive inhibitor for enzymes that interact with cyclic nucleotides, aiding in drug discovery for cardiovascular and neurological diseases.
• Signal Transduction Pathway Analysis: A key tool for probing cAMP/cGMP-dependent signaling cascades in cell biology and physiology.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) assays to identify novel therapeutic agents targeting nucleotide-binding proteins.
• Diagnostic Reagent Synthesis: Can be used as a precursor or intermediate in the development of specialized diagnostic probes and labeled nucleotides.
• Academic Research: Fundamental research tool in universities and institutes for studying nucleotide chemistry and biochemistry.

Basic Information

Product Name	Triethylammonium Uridine-3',5'-Cyclic Phosphorothioate
CAS No.	111321-64-3
Molecular Formula	C17H31N4O8PS
Molecular Weight	482.50 g/mol
Synonyms	Uridine 3',5'-cyclic phosphorothioate, triethylammonium salt; cUMPS triethylammonium salt; Uridine cyclic 3',5'-(hydrogen phosphorothioate) triethylammonium salt; Sp-Uridine-3',5'-cyclic phosphorothioate triethylamine salt; cAMP-S analog (uridine); 3',5'-cUMPS; Nucleotide analog inhibitor; PDE substrate analog
EINECS	Contact for details

Quality Control

Our Triethylammonium Uridine-3',5'-Cyclic Phosphorothioate is manufactured under controlled conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house quality protocols to guarantee product integrity, with specifications tailored to meet the demands of biochemical and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.