Description

S-3'-Deoxy-3-Deazaadenosylhomocysteine is a synthetic, non-natural analog of S-adenosylhomocysteine (SAH), a key metabolic intermediate in methylation and transsulfuration pathways. This compound is of significant value as a potent and selective inhibitor of S-adenosylhomocysteine hydrolase (SAHH), a critical enzyme in cellular methylation cycles. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for biochemical research, enzyme mechanism studies, and as a lead compound in the development of novel antiviral and anticancer therapeutics.

Application

• Biochemical Research: As a high-purity reference standard and tool compound for studying S-adenosylhomocysteine hydrolase (SAHH) inhibition and methylation-dependent processes.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the research and development of novel antiviral agents, particularly targeting viruses dependent on host methylation machinery.
• Enzymology Studies: Used to investigate the kinetics and mechanism of SAHH and related enzymes involved in one-carbon metabolism and epigenetic regulation.
• Cell Biology & Epigenetics: Employed in cellular assays to modulate intracellular SAH levels, thereby affecting methylation reactions and studying downstream effects on gene expression and cell function.
• Anticancer Research: Explored for its potential to disrupt methylation pathways critical for cancer cell proliferation and survival.
• Diagnostic Reagent Manufacturing: May be used in the formulation of diagnostic kits and reagents for clinical research related to methylation disorders.

Basic Information

Product Name	S-3'-Deoxy-3-Deazaadenosylhomocysteine
CAS No.	110880-45-0
Molecular Formula	C15H21N6O4S
Molecular Weight	381.44 g/mol
Synonyms	3-Deaza-S-tubercidinylhomocysteine; 3-Deaza-SIHA; 3-Deaza-S-adenosylhomocysteine analog; 3-Deaza-aristeromycinylhomocysteine; S-(3-Deoxy-3-deazaadenosyl)homocysteine; 3-Deaza-SAH; 3-Deaza-S-adenosyl-L-homocysteine (3-deoxy derivative); NSC 354646
EINECS	Contact for details

Quality Control

Our S-3'-Deoxy-3-Deazaadenosylhomocysteine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.