Description

2'-Deoxy-5'-o-Dmt-N6-Phenoxyacetyl-D-Adenosine is a high-purity, protected nucleoside phosphoramidite building block essential for the solid-phase synthesis of oligonucleotides. This compound is critical for ensuring high coupling efficiency and sequence fidelity in the production of synthetic DNA and RNA strands. It is primarily required by manufacturers and research institutions in the pharmaceutical, biotechnology, and diagnostic sectors engaged in antisense therapy development, PCR primer synthesis, and genetic research.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the automated solid-phase synthesis of DNA sequences.
• Antisense & siRNA Therapeutics: Production of research-grade and therapeutic oligonucleotides for gene silencing applications.
• PCR Primer & Probe Manufacture: Synthesis of high-purity primers and labeled probes for molecular diagnostics and research.
• Genetic Research Tools: Building block for creating custom DNA strands used in cloning, sequencing, and mutagenesis studies.
• Diagnostic Kit Development: Essential raw material for manufacturing components of diagnostic assays and microarrays.
• Academic & Industrial R&D: Fundamental reagent for exploratory research in biochemistry, molecular biology, and drug discovery.

Basic Information

Product Name	2'-Deoxy-5'-o-Dmt-N6-Phenoxyacetyl-D-Adenosine
CAS No.	110522-82-2
Molecular Formula	C39H41N5O8
Molecular Weight	707.78 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-phenoxyacetyl-2'-deoxyadenosine; DMT-dA(Pac) Phosphoramidite precursor; N6-Phenoxyacetyl-5'-O-dimethoxytrityl-2'-deoxyadenosine; 2'-Deoxy-5'-O-DMT-N6-pac-dA; D-Adenosine, 2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[2-(phenoxyacetyl)]-; Protected Deoxyadenosine Derivative; dA(Pac) DMT Amidite; DNA Synthesis Building Block
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5'-o-Dmt-N6-Phenoxyacetyl-D-Adenosine is manufactured under strict quality systems to meet the exacting standards of oligonucleotide synthesis. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C ± 5°C under anhydrous conditions. The product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.