Description

N6-Pheac-Deoxyadenosine is a chemically modified nucleoside analog, specifically an N6-acylated derivative of deoxyadenosine. This compound is a critical intermediate and building block in the synthesis of oligonucleotides and nucleotide-based prodrugs, where it is used to introduce specific functional groups or protect amine sites during solid-phase synthesis. It is essential for research and development in pharmaceutical chemistry, molecular biology, and diagnostic assay development, serving scientists in antiviral drug discovery, antisense therapy, and next-generation sequencing (NGS) library preparation.

Application

• Oligonucleotide Synthesis: Key phosphoramidite monomer for the solid-phase synthesis of modified DNA/RNA strands.
• Antiviral & Anticancer Prodrug Development: Serves as a precursor in the creation of nucleotide analogs targeting viral polymerases and cellular replication pathways.
• Molecular Probe Design: Used to fabricate labeled nucleotides for fluorescence in situ hybridization (FISH) and other detection techniques.
• Bioconjugation & Linker Chemistry: The Pheac (phenoxyacetyl) group acts as a versatile protecting group and a potential site for further chemical conjugation.
• Biochemical Research: Tool compound for studying enzyme kinetics, substrate specificity of nucleoside kinases, and polymerases.
• Diagnostic Reagent Manufacturing: Intermediate in the production of reagents for PCR, qPCR, and sequencing applications.

Basic Information

Product Name	N6-Pheac-Deoxyadenosine
CAS No.	110522-74-2
Molecular Formula	C19H21N5O5
Molecular Weight	399.40 g/mol
Synonyms	N6-(Phenoxyacetyl)-2'-deoxyadenosine; 2'-Deoxy-N6-(phenoxyacetyl)adenosine; N6-Phenoxyacetyl-2'-deoxyadenosine; dA(Pac); 2'-Deoxyadenosine, N6-(phenoxyacetyl)-; N6-Pac-dA; N6-Phenoxyacetyldeoxyadenosine
EINECS	Contact for details

Quality Control

Our N6-Pheac-Deoxyadenosine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for moisture and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.