Description

Adenosine 5'-[Phosporamidic Acid (5-Hydroxy-1,5-Dimethylhexyl)] Ester is a chemically modified adenosine derivative, a key intermediate in the synthesis of novel nucleotide analogs and prodrugs. This compound matters for its role in advanced pharmaceutical research, particularly in developing targeted therapies and exploring new mechanisms of action in cellular signaling pathways. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside-based drug discovery, antiviral agents, and metabolic pathway modulators.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel nucleoside-based prodrugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in studies investigating adenosine receptor signaling, nucleotide metabolism, and enzyme kinetics.
• Antiviral Drug Development: Serves as a precursor in the research and development of potential antiviral compounds targeting viral polymerases.
• Prodrug Synthesis: Utilized to create masked nucleotide analogs designed for improved cellular uptake and targeted delivery.
• Labeled Compound Preparation: A starting material for synthesizing isotopically labeled (e.g., 13C, 15N) adenosine derivatives for tracer studies.
• Enzyme Substrate Analog: Acts as a substrate or inhibitor analog in enzymatic assays for kinases and other ATP-utilizing enzymes.

Basic Information

Product Name	Adenosine 5'-[Phosporamidic Acid (5-Hydroxy-1,5-Dimethylhexyl)] Ester
CAS No.	110501-34-3
Molecular Formula	C18H30N5O7P
Molecular Weight	459.44 g/mol
Synonyms	5'-O-[(5-Hydroxy-1,5-dimethylhexyl)phosphoramidate] Adenosine; Adenosine 5'-(5-hydroxy-1,5-dimethylhexyl phosphoramidate); 5-Hydroxy-1,5-dimethylhexyl Adenosine 5'-Phosphoramidate; N-[(5-Hydroxy-1,5-dimethylhexyl)oxyphosphoryl]adenosine; Adenosine 5'-monophosphoramidate (5-hydroxy-1,5-dimethylhexyl) ester; Acyclic Nucleoside Phosphonate Prodrug Intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Adenosine 5'-[Phosporamidic Acid (5-Hydroxy-1,5-Dimethylhexyl)] Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.