Description

2'-Bromo-2'-Deoxy-3',5'-Di-o-Acetyl-5-Methyluridine is a crucial nucleoside derivative and a key synthetic intermediate in the production of modified oligonucleotides. This compound matters because it enables the precise introduction of bromine and methyl functionalities into nucleic acid chains, allowing researchers to study and manipulate genetic material. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antisense therapy development, diagnostic probe synthesis, and advanced nucleotide chemistry.

Application

• Antisense Oligonucleotide Synthesis: A vital building block for creating modified oligonucleotides used in gene silencing and therapeutic applications.
• Diagnostic Probe Development: Used in the manufacture of labeled probes for genetic testing and molecular diagnostics.
• Medicinal Chemistry Research: Serves as a key intermediate in the discovery and development of novel nucleoside-based antiviral and anticancer agents.
• Bioconjugation and Labeling: The bromine moiety provides a reactive handle for further chemical modifications and attachment of reporter molecules.
• Academic & Industrial R&D: Essential for fundamental studies in nucleic acid structure, function, and stability.
• Precursor for Advanced Intermediates: Used in the synthesis of other specialized nucleoside analogs with tailored biological properties.

Basic Information

Product Name	2'-Bromo-2'-Deoxy-3',5'-Di-o-Acetyl-5-Methyluridine
CAS No.	110483-43-7
Molecular Formula	C₁₄H₁₇BrN₂O₇
Molecular Weight	405.20 g/mol
Synonyms	5-Methyl-2'-bromo-2'-deoxy-3',5'-di-O-acetyluridine; 2'-Bromo-5-methyl-2'-deoxyuridine 3',5'-diacetate; 1-[(2R,3R,4R,5R)-3-Acetoxy-5-(acetoxymethyl)-4-bromotetrahydrofuran-2-yl]-5-methylpyrimidine-2,4-dione; 2'-Bromo-5-methyl-2'-deoxyuridine diacetate; BrdUrd diacetate (ambiguous, context-specific); 2'-Bromo-5-methyluridine 3',5'-di-O-acetate
EINECS	Contact for details

Quality Control

Our 2'-Bromo-2'-Deoxy-3',5'-Di-o-Acetyl-5-Methyluridine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.