Description

2-((3-Bromo-2-Oxopropyl)Thio)Adenosine 2',5'-Bisphosphate is a chemically modified nucleotide analog that serves as a potent and selective inhibitor of certain nucleotide-metabolizing enzymes. This compound matters for researchers and developers in life sciences as a critical biochemical tool for probing cellular signaling pathways and enzyme mechanisms. It is primarily needed by pharmaceutical R&D teams, academic biochemists, and diagnostic kit manufacturers focused on nucleotide metabolism, purinergic signaling, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a high-affinity substrate analog and inhibitor in enzymatic studies, particularly for enzymes acting on adenosine phosphates.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the discovery of drugs targeting metabolic disorders and inflammatory pathways.
• Cell Signaling Studies: Employed to investigate and modulate purinergic receptor signaling cascades in various cell types.
• Diagnostic Reagent Formulation: Acts as a specialized component in assay kits for measuring specific enzyme activities in clinical and research settings.
• Metabolic Pathway Analysis: A tool for tracing and inhibiting specific branches of nucleotide metabolism in metabolic engineering and disease model research.

Basic Information

Product Name	2-((3-Bromo-2-Oxopropyl)Thio)Adenosine 2',5'-Bisphosphate
CAS No.	110356-02-0
Molecular Formula	C₁₃H₁₈BrN₅O₁₂P₂S
Molecular Weight	634.22 g/mol
Synonyms	2-[(3-Bromo-2-oxopropyl)thio]adenosine 2',5'-bisphosphate; 2',5'-ADP-S-BOP; 2-((3-Bromo-2-oxopropyl)thio)-adenosine-2',5'-bisphosphate; Adenosine-2',5'-bisphosphate, 2-[(3-bromo-2-oxopropyl)thio]-; BOT-Ad-2',5'-PP; 2'-Phosphoadenosine 5'-phosphate 2-(3-bromo-2-oxopropyl)thioether; 2-[(3-Bromo-2-oxopropyl)thio]-9-β-D-ribofuranosyladenine 2',5'-bis(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our 2-((3-Bromo-2-Oxopropyl)Thio)Adenosine 2',5'-Bisphosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.