Description

Methyl 8-(2''-Hydroxyethoxy)-2',3'-o-Isopropylideneadenosine-5',2''-Phosphate is a sophisticated, high-purity nucleoside derivative used as a critical intermediate in advanced pharmaceutical synthesis. This compound is essential for researchers and manufacturers developing novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. Its unique protected structure makes it a valuable building block for the synthesis of modified nucleotides and prodrugs, targeting the global life sciences and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel adenosine-based antiviral and anticancer prodrugs.
• Nucleotide Chemistry Research: Used in academic and industrial R&D for studying nucleotide metabolism and designing enzyme inhibitors.
• Prodrug Synthesis: Serves as a protected intermediate for creating phosphate-containing prodrugs with enhanced bioavailability.
• Bioconjugation & Labeling: Potential use in the preparation of labeled nucleotides for diagnostic assays and imaging probes.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Fine Chemical Manufacturing: Employed in custom synthesis and contract manufacturing of high-value specialty chemicals.

Basic Information

Product Name	Methyl 8-(2''-Hydroxyethoxy)-2',3'-o-Isopropylideneadenosine-5',2''-Phosphate
CAS No.	110090-92-1
Molecular Formula	C17H24N5O9P
Molecular Weight	473.38 g/mol
Synonyms	8-[2-(Hydroxyethoxy)]-2',3'-O-isopropylideneadenosine 5'-(methyl phosphate); 2',3'-O-Isopropylidene-8-[2-(hydroxyethoxy)]adenosine 5'-(methyl phosphate); Methyl (2',3'-O-isopropylidene-8-[2-(hydroxyethoxy)]adenosin-5'-yl) phosphate; Adenosine, 8-[2-(hydroxyethoxy)]-2',3'-O-(1-methylethylidene)-, 5'-(methyl phosphate); Protected Adenosine Phosphate Ester; Nucleoside Phosphate Intermediate
EINECS	Contact for details

Quality Control

Our Methyl 8-(2''-Hydroxyethoxy)-2',3'-o-Isopropylideneadenosine-5',2''-Phosphate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP-grade synthesis. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to stringent analytical protocols, including HPLC, NMR, and MS, to guarantee the product meets the exacting standards required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Single Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.