Description

Cyclobutanecarbonyl Chloride, 1-Methoxy- (9Ci) is a specialized organic acid chloride derivative of cyclobutane, serving as a critical building block in advanced synthetic chemistry. Its value lies in its unique sterically constrained four-membered ring structure, which is leveraged to introduce specific conformational properties into target molecules. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and complex organic frameworks.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those requiring conformationally restricted scaffolds for enhanced biological activity and selectivity.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the cyclobutane ring can contribute to unique modes of action.
• Material Science Research: Employed in the creation of specialized polymers and advanced organic materials with tailored thermal or mechanical properties.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation or as a precursor for activity-based probes in studying enzyme function.
• Academic & Process R&D: A valuable reagent for methodological development in organic synthesis, including studies on ring strain and reaction mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial quantities for client-specific projects.

Basic Information

Product Name	Cyclobutanecarbonyl Chloride, 1-Methoxy- (9Ci)
CAS No.	110046-66-7
Molecular Formula	C6H9ClO2
Molecular Weight	148.59 g/mol
Synonyms	1-Methoxycyclobutanecarbonyl chloride; 1-Methoxycyclobutane-1-carboxylic acid chloride; 1-Methoxy-1-cyclobutanecarbonyl chloride; (1-Methoxycyclobutyl)carbonyl chloride; Cyclobutanecarboxylic acid, 1-methoxy-, chloride (9CI); 1-Methoxycyclobutanecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Every batch of Cyclobutanecarbonyl Chloride, 1-Methoxy- (9Ci) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature and reactivity as an acid chloride, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and protected from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.