Description

3-o-Methyl 6-Hydroxy 17β-Estradiol CAS NO 109835-83-8 is a high-purity, synthetically derived estrogen derivative, serving as a critical intermediate in advanced pharmaceutical research and development. This compound is valued for its specific structural modifications, which are essential for studying metabolic pathways and developing novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in endocrinology, oncology, and the synthesis of steroidal drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroidal drugs and hormone therapies.
• Biochemical Research: Used as a reference standard and probe in studies of estrogen receptor binding and metabolic pathways.
• Academic & Contract Research: Essential for university labs and CROs (Contract Research Organizations) conducting fundamental endocrinology research.
• Drug Discovery & Development: Employed in the R&D pipeline for creating targeted treatments for hormone-related conditions.
• Analytical Standard: Serves as a high-purity standard for method development and quality control in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	3-o-Methyl 6-Hydroxy 17β-Estradiol
CAS No.	109835-83-8
Molecular Formula	C19H26O3
Molecular Weight	302.41 g/mol
Synonyms	3-Methoxyestra-1,3,5(10)-triene-6,17β-diol; 6-Hydroxy-3-methoxyestra-1,3,5(10)-trien-17β-ol; 3-Methoxy-6-hydroxyestradiol; 3-O-Methyl-6-hydroxy-17β-estradiol; 6-Hydroxy-3-methoxy-17β-estradiol; Estra-1,3,5(10)-triene-3,6,17-triol, 3-methyl ether; 17β-Estradiol 3-methyl ether 6-ol
EINECS	Contact for details

Quality Control

Our 3-o-Methyl 6-Hydroxy 17β-Estradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.