Description

5,6-Dihydroxy-5,6-Dihydro-2'-Deoxyuridine is a chemically modified nucleoside derivative, serving as a critical intermediate and reference standard in advanced biochemical research and pharmaceutical development. Its unique dihydroxylated structure makes it a valuable tool for studying DNA damage, repair mechanisms, and the metabolic pathways of nucleoside analogs. This compound is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in the development of antiviral agents, oncology therapeutics, and molecular biology reagents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a reference standard and substrate in studies of DNA oxidation, repair enzymes like glycosylases, and free radical damage mechanisms.
• Diagnostic Development: Serves as a critical component in the formulation of calibration standards and reagents for diagnostic assays detecting oxidative DNA damage biomarkers.
• Academic Research: Employed in universities and research institutes for investigating the biological consequences and repair of thymine glycol lesions in DNA.
• Standards & Metrology: Provides a high-purity certified reference material (CRM) for quality control in laboratories performing genetic toxicology testing.

Basic Information

Product Name	5,6-Dihydroxy-5,6-Dihydro-2'-Deoxyuridine
CAS No.	109525-66-8
Molecular Formula	C9H12N2O6
Molecular Weight	244.20 g/mol
Synonyms	5,6-Dihydroxy-5,6-dihydrothymidine; 5,6-Dihydroxydihydrothymidine; Thymine glycol (2'-deoxyriboside); 5,6-Dihydroxy-5,6-dihydro-2'-deoxythymidine; 2'-Deoxy-5,6-dihydroxy-5,6-dihydrouridine; 5,6-Dihydroxydihydro-2'-deoxyuridine; dThg; 5,6-DHTG
EINECS	Contact for details

Quality Control

Every batch of 5,6-Dihydroxy-5,6-Dihydro-2'-Deoxyuridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as assay purity (by HPLC), identity confirmation (by IR/UV), and levels of specific impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.