Description

27-Dehydrowithaferin A is a specialized, high-purity steroidal lactone derivative, a key intermediate and reference standard in advanced pharmaceutical and phytochemical research. This compound matters for its critical role in the study of withanolide biosynthesis and as a precursor for developing novel therapeutic agents. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and manufacturers of high-value botanical extracts focusing on anti-inflammatory, anti-cancer, and immunomodulatory applications.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification, purity assessment, and quantification of withanolides in complex matrices via HPLC and LC-MS.
• Biochemical Research: Serves as a crucial intermediate and probe in studying the structure-activity relationships (SAR) and biosynthesis pathways of withanolide-class compounds.
• Natural Product Synthesis: Acts as a key starting material or intermediate for the semi-synthesis of novel withanolide analogs with potential enhanced bioactivity.
• Botanical Extract Standardization: Employed in the quality control and standardization of extracts derived from Withania somnifera (Ashwagandha) and other Solanaceae plants.
• In-vitro Bioactivity Screening: Utilized in cell-based assays to investigate potential anti-proliferative, anti-angiogenic, and anti-inflammatory properties.

Basic Information

Item	Detail
Product Name	27-Dehydrowithaferin A
CAS No.	109357-42-8
Molecular Formula	C28H36O7
Molecular Weight	484.58 g/mol
Synonyms	27-Dehydro-withaferin A; (22R)-5,6:22,26-Diepoxy-4,27-dihydroxy-1-oxoergosta-2,24-dien-26-oic acid γ-lactone; 27-Dehydro-withaferin A; Withaferin A derivative; 27-Dehydro WA; 27-Dehydro Withanolide A derivative; 27-DHWA
EINECS	Contact for details

Quality Control

Our 27-Dehydrowithaferin A is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, IR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements of research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.