Description

(R)-Terazosin CAS NO 109351-34-0 is a high-purity, single-enantiomer pharmaceutical intermediate and active ingredient. This compound is the (R)-enantiomer of Terazosin, a selective α-1 adrenergic receptor antagonist, and is critical for research into stereospecific drug activity and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of advanced chiral molecules for cardiovascular and urological applications.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure Terazosin and its derivatives.
• Pharmacological Research: Used in preclinical studies to investigate the stereoselective binding and activity of α-1 adrenergic receptor antagonists.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Process Chemistry Development: Employed in optimizing asymmetric synthesis routes and chiral separation techniques.
• Academic Research: Utilized in university and institutional labs for studies in medicinal chemistry and cardiovascular pharmacology.

Basic Information

Product Name	(R)-Terazosin
CAS No.	109351-34-0
Molecular Formula	C₁₉H₂₅N₅O₄
Molecular Weight	387.44 g/mol
Synonyms	(R)-Terazosin; (R)-Terazosin Hydrochloride; (R)-Terazosin Dihydrate; (R)-α-1 Adrenergic Blocker; (R)-Hytrin; (2R)-2-[4-(Tetrahydro-2-furanyl)carbonyl]-1-piperazinyl]-6,7-dimethoxy-4-quinazolinamine; (R)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furoyl)piperazine]; Terazosin (R)-enantiomer
EINECS	Contact for details

Quality Control

Our (R)-Terazosin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) providing results for identity, purity, and chiral excess is supplied with every shipment. We support compliance with cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.