Description

Purine -9-β-D-(2'-Deoxy-2'-Fluoro) Arabinoriboside is a modified nucleoside analog, a key building block in medicinal chemistry and pharmaceutical research. Its value lies in its structural role as a precursor for the synthesis of antiviral and anticancer nucleotide analogs, particularly those targeting viral polymerases. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of antiviral drugs, especially nucleoside reverse transcriptase inhibitors (NRTIs).
• Anticancer Drug Development: Used in research and production of nucleotide analogs designed to inhibit cancer cell proliferation.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving viral polymerases like HIV reverse transcriptase.
• Pro-drug Synthesis: A key starting material for creating more bioavailable pro-drug forms of active nucleotide therapeutics.
• Labeled Compound Production: Used to synthesize radiolabeled or fluorescently tagged analogs for pharmacokinetic and metabolic studies.

Basic Information

Product Name	Purine -9-β-D-(2'-Deoxy-2'-Fluoro) Arabinoriboside
CAS No.	109304-16-7
Molecular Formula	C14H16FN5O4
Molecular Weight	337.31 g/mol
Synonyms	2'-Fluoro-2'-deoxy-β-D-arabinofuranosylpurine; 9-[(2R,3S,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purine; 2'-F-ara-P; 2'-Fluoro-2'-deoxy-β-D-arabinofuranosyladenine (common misnomer); β-D-2'-Fluoro-2'-deoxyarabinofuranosylpurine; 2'-F-dAraP; 2'-Fluoro-arabinofuranosylpurine
EINECS	Contact for details

Quality Control

Our Purine -9-β-D-(2'-Deoxy-2'-Fluoro) Arabinoriboside is manufactured under strict quality systems suitable for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.