Description

2-Aminopurine -9-β-D-(2'-Deoxy-2'-Fluoro)Arabino-Riboside is a fluorinated nucleoside analog, a key building block in medicinal chemistry and biochemical research. Its modified sugar moiety, featuring a 2'-deoxy-2'-fluoro-arabinose configuration, is critical for enhancing the metabolic stability and binding affinity of oligonucleotide therapeutics. This high-purity intermediate is essential for researchers and manufacturers developing novel antiviral agents, antisense oligonucleotides, and diagnostic probes, where precise molecular structure dictates biological activity.

Application

• Antiviral Drug Development: Serves as a critical precursor in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds targeting viral polymerases.
• Antisense Oligonucleotide (ASO) Synthesis: Incorporated into oligonucleotide sequences to modulate RNA function, enhance nuclease resistance, and improve therapeutic efficacy for genetic disorders.
• siRNA and miRNA Research: Used in the chemical modification of small interfering RNA (siRNA) and microRNA (miRNA) to improve pharmacokinetic properties and target specificity.
• Fluorescent Nucleotide Analogs: The 2-aminopurine base acts as an intrinsic fluorescent probe for studying nucleic acid structure, dynamics, and protein-nucleic acid interactions.
• Diagnostic Probe Manufacturing: Employed in creating labeled nucleotides for diagnostic assays, including PCR and sequencing applications.
• Medicinal Chemistry & Lead Optimization: A valuable scaffold for structure-activity relationship (SAR) studies in drug discovery programs focused on nucleoside-based targets.

Basic Information

Product Name	2-Aminopurine -9-β-D-(2'-Deoxy-2'-Fluoro)Arabino-Riboside
CAS No.	109304-04-3
Molecular Formula	C15H15FN6O4
Molecular Weight	354.32 g/mol
Synonyms	9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2-aminopurine; 2-Aminopurine-9-(2-deoxy-2-fluoro-β-D-arabinofuranoside); 2-Aminopurine 2'-F-ara nucleoside; 2-Aminopurine-2'-F-ANA; 2-Ap-2'-F-ANA; 2-Amino-9-[(2R,3S,4S,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purine; 2-Aminopurine 2'-fluoroarabinonucleoside
EINECS	Contact for details

Quality Control

Our 2-Aminopurine -9-β-D-(2'-Deoxy-2'-Fluoro)Arabino-Riboside is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.