Description

2-Fluoro-6-(trifluoromethyl)benzoyl chloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of fluorine and trifluoromethyl substituents, which are essential for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediates: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the fluorine motifs enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic cores in electronic materials, improving thermal stability and optical properties.
• Polymer Chemistry: Employed as a monomer or modifier to introduce fluorinated benzoyl groups into polymer chains, altering surface properties and chemical resistance.
• Peptide & Protein Modification: Acts as an acylating agent for selective modification of amino groups in biomolecules for research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A versatile reagent for custom chemical synthesis services catering to specialized R&D projects across multiple industries.

Basic Information

Item	Detail
Product Name	2-Fluoro-6-(trifluoromethyl)benzoyl Chloride
CAS No.	109227-12-5
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	2-Fluoro-6-(trifluoromethyl)benzoyl chloride; 2-Fluoro-alpha,alpha,α-trifluoro-o-toluoyl chloride; o-Trifluoromethyl-2-fluorobenzoyl chloride; 2-Fluoro-6-trifluoromethylbenzoyl chloride; Benzoyl chloride, 2-fluoro-6-(trifluoromethyl)-; 6-Trifluoromethyl-2-fluorobenzoyl chloride; 2-Fluoro-α,α,α-trifluoro-o-toluoyl chloride
EINECS	Contact for details

Quality Control

Every batch of our 2-Fluoro-6-(trifluoromethyl)benzoyl chloride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.