Description

(2S,3S,5R)-5-(6-Amino-9H-Purin-9-Yl)-2-((Phenylthio)Methyl)Tetrahydrofuran-3-Ol CAS NO 108906-82-7 is a high-purity nucleoside analogue derivative, a key chiral intermediate in advanced pharmaceutical synthesis. This compound matters for its critical role in the development of antiviral and anticancer therapeutics, where precise stereochemistry is essential for biological activity. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the production of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Antiviral Drug Research: Used in the development of prodrugs and active metabolites targeting viral polymerases.
• Oncology Research: Serves as a precursor for experimental chemotherapeutic agents that interfere with DNA/RNA synthesis.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and GMP manufacturing of complex chiral molecules.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory filings.

Basic Information

Product Name	(2S,3S,5R)-5-(6-Amino-9H-Purin-9-Yl)-2-((Phenylthio)Methyl)Tetrahydrofuran-3-Ol
CAS No.	108906-82-7
Molecular Formula	C₁₇H₁₉N₅O₂S
Molecular Weight	357.43 g/mol
Synonyms	9-[(2S,3S,5R)-3-Hydroxy-5-[(phenylthio)methyl]tetrahydrofuran-2-yl]-9H-purin-6-amine; 6-Amino-9-[(2S,3S,5R)-3-hydroxy-5-[(phenylthio)methyl]tetrahydrofuran-2-yl]purine; (2S,3S,5R)-2-[(Phenylthio)methyl]-5-(6-aminopurin-9-yl)oxolane-3-ol; Nucleoside Phenylthio Derivative; Adenine Phenylthiomethyl Tetrahydrofuranol Derivative; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our (2S,3S,5R)-5-(6-Amino-9H-Purin-9-Yl)-2-((Phenylthio)Methyl)Tetrahydrofuran-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.