Description

2-Propenoyl Chloride, 3-(4-Hydroxyphenyl)-, (2E)- is a specialized, high-purity chemical intermediate featuring a phenolic hydroxyl group and an acryloyl chloride moiety. This compound is valued for its dual reactivity, enabling its use as a key building block in the synthesis of advanced functional materials and active pharmaceutical ingredients. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and specialty polymer industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting hormone receptors or requiring phenolic ester linkages.
• Polymer Chemistry: Used to introduce photo-crosslinkable or UV-reactive groups into specialty polymers, resins, and coatings for advanced material properties.
• Agrochemical Synthesis: Serves as a building block for creating active ingredients in crop protection agents with specific targeting and delivery mechanisms.
• Liquid Crystal & OLED Materials: Employed in the production of advanced organic electronic materials where its molecular structure contributes to desired optical and electronic characteristics.
• Bioconjugation & Linker Chemistry: Useful for creating cleavable or stable linkers in antibody-drug conjugates (ADCs) and other bioconjugate applications.
• Academic & Industrial Research: A valuable reagent for exploring new synthetic pathways and developing novel compounds in chemical research laboratories.

Basic Information

Item	Details
Product Name	2-Propenoyl Chloride, 3-(4-Hydroxyphenyl)-, (2E)-
CAS No.	108608-03-3
Molecular Formula	C9H7ClO2
Molecular Weight	182.60 g/mol
Synonyms	(2E)-3-(4-Hydroxyphenyl)acryloyl chloride; trans-4-Hydroxycinnamoyl chloride; (E)-3-(4-Hydroxyphenyl)prop-2-enoyl chloride; p-Hydroxycinnamic acid chloride; 4-Hydroxycinnamoyl chloride; (E)-4-Hydroxycinnamoyl chloride; 3-(4-Hydroxyphenyl)-2-propenoyl chloride
EINECS	Contact for details

Quality Control

Our 2-Propenoyl Chloride, 3-(4-Hydroxyphenyl)-, (2E)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.