Description

P(1)-(5'-Adenosyl)-P(2)-n-(2-Mercaptoethyl)Diphosphoramidate is a specialized biochemical compound featuring a unique diphosphoramidate linkage between an adenosine moiety and a 2-mercaptoethylamine group. This molecular architecture makes it a valuable synthetic intermediate and research tool for studying nucleotide metabolism, enzyme mechanisms, and signal transduction pathways. It is primarily utilized by research scientists and process developers in the pharmaceutical, biotechnology, and life science sectors for advanced biochemical research and the development of novel therapeutic agents.

Application

• Biochemical Research: As a substrate or inhibitor in enzymatic studies related to adenosyl transfer and sulfur metabolism.
• Pharmaceutical Intermediates: Serving as a key building block in the synthesis of novel nucleotide analogs and prodrugs.
• Enzyme Mechanism Probes: Investigating the catalytic mechanisms of phosphoramidate-utilizing enzymes.
• Metabolic Pathway Analysis: A tool for tracing and understanding complex biochemical pathways involving modified nucleotides.
• Antiviral/Anticancer Agent Development: Exploration of its potential or its derivatives in medicinal chemistry programs targeting viral replication or cell proliferation.
• Labeling and Detection Reagents: Potential use in creating labeled probes for diagnostic assays due to its reactive thiol group.

Basic Information

Item	Detail
Product Name	P(1)-(5'-Adenosyl)-P(2)-n-(2-Mercaptoethyl)Diphosphoramidate
CAS No.	108490-60-4
Molecular Formula	C12H20N7O10P2S
Molecular Weight	507.33 g/mol
Synonyms	Adenosyl Diphosphoramidate Mercaptoethyl Derivative; 5'-Adenosyl P-1,P-2-di(n-2-mercaptoethyl)diphosphoramidate; 2-Aminoethanethiol Adenylyl Diphosphoramidate; Ado-2-SH-Et-DPAm; Adenosine 5'-(P-1-(2-mercaptoethylamido)-P-2-diphosphate); Research Compound 108490-60-4
EINECS	Contact for details

Quality Control

Our P(1)-(5'-Adenosyl)-P(2)-n-(2-Mercaptoethyl)Diphosphoramidate is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. All batches undergo rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., argon or nitrogen) in a cool, dry place. For long-term stability, storage at -20°C is recommended. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.